Poly(vinyl alcohol)/Pullulan Composite Hydrogels as a Potential Platform for Wound Dressing Applications

Hydrogels are 3D networks with an excellent ability to retain a high amount of water or biological fluids, representing suitable candidates for wound dressing applications. They can provide protective barrier and moist environment, facilitating treatment. The present paper focuses on physical hydrogels obtained from poly(vinyl alcohol) (PVA) pullulan (PULL) mixtures in different weight ratios by using the freezing/thawing method. Hybrid similar polymer compositions were prepared presence 0.5% Laponite® RD. influence polysaccharide clay addition properties PVA was investigated. Scanning electron microscopy showed evidence inner porous structure. viscoelastic investigated shear conditions revealed hydrogel composition network strength. swelling behavior followed physiological saline solutions at 37 °C pH = 7.4. For all samples, quasi-Fickian diffusion mechanism found. delivery neomycin sulfate studied as tests (0.15 M NaCl solutions; °C; 7.4) kinetic models used determine release mechanism. Peppas–Sahlin approach described very well vitro drug polymeric absence clay. However, hybrid polymer/clay best fit Korsmeyer–Peppas model. According study, membranes containing 40–60% PULL (in clay) therapeutic agents sites conditions.